Learning Cardiology

Q. Which of the following is true about Brugada syndrome? A. AR inheritance B. Exertional syncope C. Functional phase 2 re-entry D. Female preponderance Answer: C. Functional phase 2 re-entry Explanation: Brugada syndrome: Cause of ventricular arrhythmia in structurally normal heart. Autosomal dominant genetic disorder. Loss of function genetic mutation in cardiac sodium channels (SCN5A and SCN10A). Functional phase 2 re-entry leads to ventricular arrhythmias in Brugada. ECG: Right bundle branch pattern with ST elevation in V1 to V3 leads. Types of Brugada syndrome (Image 1): Type 1: Coved type ST elevation (>/=2 mm) with inverted T waves Type 2:  Saddle-back ST-T wave configuration with an upright or biphasic T wave                                     Image 1: Types of Brugada syndrome  Brugada pattern ECG is more common in...