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Bempedoic acid

 Bempedoic Acid


A novel nonstatin drug that inhibits cholesterol biosynthesis in liver.

Prodrug → converted to active form in liver, not in muscles.

# Mechanism of action → ATP-citrate lyase inhibitor.


• No muscular side effects.

• Does not worsen glycemic control

• side effects → Hyperuricemia and gout

 Slightly increased risk of tendon rupture


⇒ Major clinical trial - CLEAR wisdom and CLEAR Outcomes


⇒ Indications at present:

1. LDL not effectively reduced with statins -As additional therapy

2. Patients not tolerating stating due to side effects -As monotherapy

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