Q. Which of the following is not an absolute contraindication of Sacubitril/valsartan combination?
A. History of hypersensitivity to valsartan
B. History of hyperkalemia with valsartan
C. 1st trimester of pregnancy
D. History of angioedema with ACE inhibitors
Answer: B. History of hyperkalemia with valsartan
Absolute contraindications of sacubitril include
1. History of hypersensitivity to any of component of sacubitril
2. H/o angioedema due to ACE inhibitors or ARBs
3. Pregnancy
Past history of hyperkalemia with valsartan is not a contraindication for the use of sacubitril as such potassium should be normal while starting it. However, potassium level should be monitored more carefully in these patients. Hence, sacubitril can be given to patients who have past history of hyperkalemia due to any cause.
A. History of hypersensitivity to valsartan
B. History of hyperkalemia with valsartan
C. 1st trimester of pregnancy
D. History of angioedema with ACE inhibitors
Answer: B. History of hyperkalemia with valsartan
Absolute contraindications of sacubitril include
1. History of hypersensitivity to any of component of sacubitril
2. H/o angioedema due to ACE inhibitors or ARBs
3. Pregnancy
Past history of hyperkalemia with valsartan is not a contraindication for the use of sacubitril as such potassium should be normal while starting it. However, potassium level should be monitored more carefully in these patients. Hence, sacubitril can be given to patients who have past history of hyperkalemia due to any cause.
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