Skip to main content

MCQ 41. Digoxin

Q.  A patient with atrial fibrillation was prescribed digoxin. What does it bind to in order to generate its mode of action?
A. Calcium channel
B. Potassium channel
C.  Na-Ca transporter
D. Na / K- ATPase 

Answer: D.  Na / K- ATPase 
Explanation: 
Digoxin belongs to cardiac glycoside group of medications.
It is obtained from foxglove plant.
Half life is 36 hours.
Mechanism of action: Inhibition of Na/K ATPase and ultimately increased intracellular calcium.
Eliminated mainly by renal excretion through P-glycoproteins.
Narrow therapeutic index.
Can cause gynecomastia.
Effective plasma level between 0.5 to 1.0 ng/ml.

Labels:

Comments

Post a Comment

Popular posts from this blog

ECG Spotter

What is the diagnosis? Click the button below to view answer: Show Answer
Post a Comment
Read more

High heart rate

The patient contacts the doctor over phone with this report.   Obviously anxious because of his high heart rate (199 beats per minute) as detected by ECG machine.  Should he be worried about this and come to emergency department as soon as possible? Correct answer-  ECG machine has calculated his heart rate incorrectly.  Heart rate is around 100 beats per minute.  Other findings in this ECG include ST segment elevation in anterior chest leads along with presence of Q waves, denoting old MI changes with possibly development of LV aneurysm. In such cases, ST segment elevation can persist for long periods.    Now, should he come to emergency department? Not because of detection of high heart rate.  But, if he is having symptoms such as shortness of breath or chest pain, he should visit emergency department. Otherwise, if he is asymptomatic, he can schedule a regular visit with his cardiologist. 
Post a Comment
Read more

Cardiology Multiple choice questions (MCQs)- Arrhythmia

Post a Comment
Read more